Researchers find clues to SARS-CoV-2 infection and explore why COVID-19 impacts patients differently

Working together, researchers at McMaster University and the University of Waterloo are searching for how the SARS-CoV-2 virus infects the lungs – and they’re challenging what has become an accepted truth about the virus. Working together, researchers at McMaster University and the University of Waterloo are searching for how the SARS-CoV-2 virus infects the lungs – and they’re challenging what has become an accepted truth about the virus.

Researchers find clues to SARS-CoV-2 infection and explore why COVID-19 impacts patients differently

Previously, scientists have determined that entry of SARS-CoV-2 into cells occurs through a receptor on the cell surface, known as ACE2. But the McMaster-Waterloo team has found that the ACE2 receptor is at very low levels in human lung tissue.

“Our finding is somewhat controversial, as it suggests that there must be other ways, other receptors for the virus, that regulate its infection of the lungs,” said Jeremy Hirota, co-lead scientist of the team from the Research Institute of St. Joe’s Hamilton and an Assistant Professor of Medicine at McMaster....

https://uwaterloo.ca/stories/news/researchers-find-clues-sars-cov-2-infection-and-explore-why